Gram negative bacteria cause numerous infections including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis. These bacteria are resistant to multiple drugs and are increasingly resistant to most available antibiotics.
Gram-negative bacteria include many common pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, and a large family of related enteric bacteria including Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, and many others. Gram-negative bacterial infections can be as benign as Swimmer’s Ear to very serious diseases such as food poisoning, meningitis, Legionnaires’ disease, plague, cholera, dysentery, and sexually transmitted diseases such as gonorrhea.
Infections caused by Gram-negative bacteria can be difficult to treat because of their unique features, including the nature of their cell wall which makes them resistant to several classes of antibiotics.
Certain types of Gram-negative bacteria have become increasingly resistant to nearly all available antibiotic drugs. This has also increased illness and death from bacterial infections, heightened the challenge for healthcare facilities, and contributed to escalating healthcare costs.
Treatment with GN-4474 () reduced infection by an average of 98%, and half the animals showed no signs of infection compared to untreated controls ().
Furthermore, treatment with GN-4474 prevented sepsis in the same animals (not shown).